CardioCHEK™
Microwell ELISA Assays
Quantitative Human Plasma Assays for
Coronary Heart
Disease
(CHD) Risk Factors
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Apo AI
Cat. No.
A70101
Price:
$250.00
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Apolipoprotein
A1 (product insert):
Apo
AI is primarily found in high density lipoprotein (HDL) particle. It serves the function of
preventing the accumulation of cholesterol loaded macrophages which
deposit on the arterial wall as foam cells.
This is the prominent early
feature of atherosclerotic lesion formation ultimately resulting in
atherosclerosis. Apo
AI, is a single polypeptide with a molecular weight of 28 Kd. Its primary function is to
activate LCAT within the HDL complex, which catalyzes the
esterification of cholesterol. This
results in a more soluble cholesterol-HDL complex which increases the
cholesterol transport capacity of the
HDL particle for subsequent removal by the liver.
Apo AI is therefore a convenient marker for
assessing the cholesterol clearing capacity of the blood, and studies
have clearly indicated that it is a better discriminator of
angiographically documented coronary artery disease than HDL
cholesterol.
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| Apo B
Cat. No.
A70102
Price:
$250.00 |
Apolipoprotein
B (product insert):
Over 90% of low density
lipoprotein
(LDL) particle is composed of Apo B. It
serves the function of solubalizing cholesterol within the LDL complex,
which in turn increases the transport capacity of LDL for subsequent
deposit on the arterial wall. Apo
B is therefore a convenient marker for assessing the cholesterol
depositing capacity of the blood, and studies have clearly indicated it
as a better discriminator of angiographically documented coronary
artery disease than LDL cholesterol.
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Lp(a)
Cat. No.
A70103
Price:
$250.00 |
Lipoprotein(a)
(product insert):
Lp(a), unlike Apo AI or Apo B,
whose levels vary as a result of diet, exercise, etc. is predominantly
a genetic trait whose level remains more or less constant after puberty. More than 13 phenotypes of
Lp(a) have been identified having molecular weight of 300-800 Kd. It is bound to both HDL
and LDL. Lp(a) interferes with plasminogen, the clot dissolving enzyme,
which binds to the arterial endothelial lining.
This in turn contributes to blood clot formation,
and over a prolonged period of time would lead to significant damage to
the coronary arteries. Levels
of greater than 30mg/dl have been demonstrated to independently
increase the risk of CHD by six fold. |
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CRP
Cat. No.
A70104
Price:
$250.00
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C-Reactive
Protein (product insert):
C-Reactive Protein
(CRP) has
been demonstrated to be a general indicator of major tissue damage.
Hence, it can be used to indicate a stroke or heart attack because
major blood vessels leading to the heart or brain are damaged and
release large quantities of CRP during these disease states. CRP is a
particularly useful indicator of CHD in women and in patients that
demonstrate no other plasma circulating biochemical indicators.
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